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Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.
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- Komohara Yoshihiro
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Ma Chaoya
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Yano Hiromu
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Pan Cheng
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Horlad Hasita
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Saito Yoichi
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Ohnishi Koji
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Fujiwara Yukio
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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- Okuno Yutaka
- Department of Hematology, Graduate School of Medical Sciences, Kumamoto University
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- Nosaka Kisato
- Department of Hematology, Graduate School of Medical Sciences, Kumamoto University
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- Shimosaki Shunsuke
- Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki
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- Morishita Kazuhiro
- Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki
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- Matsuoka Masao
- Department of Hematology, Graduate School of Medical Sciences, Kumamoto University Laboratory of Virus Control, Institute for Virus Research, Kyoto University
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- Wakayama Tomohiko
- Department of Histology, Graduate School of Medical Sciences, Kumamoto University
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- Takeya Motohiro
- Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
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Description
<p>Cell adhesion molecule 1 (CADM1) is a cell adhesion molecule that is expressed in brain, liver, lung, testis, and some kinds of cancer cells including adult T-cell leukemia/lymphoma (ATLL). Recent studies have indicated the involvement of CADM1 in cell-cell contact between cytotoxic T-lymphocytes and virus infected cells. We previously reported that cell-cell interaction between lymphoma cells and macrophages induces lymphoma cell proliferation. In the present study, we investigated whether CADM1 is associated with cell-cell interaction between several human lymphoma cell lines and macrophages.</p><p>CADM1 expression was observed in the ATLL cell lines, ATN-1, ATL-T, and ATL-35T, and in the B cell lymphoma cell lines, TL-1, DAUDI, and SLVL, using western blotting. Significant cell-cell interaction between macrophages and ATN-1, ATL-T, ATL-35T and MT-2, DAUDI, and SLVL cells, as assessed by induction of cell proliferation, was observed. Immunohistochemical analysis of human biopsy samples indicated CADM1 expression in 10 of 14 ATLL cases; however, no case of follicular lymphoma or diffuse large B-cell lymphoma was positive for CADM1. Finally, the interaction of macrophages with cells of the CADM1-negative ED ATLL cell line and CADM1-transfected ED cells was tested. However, significant cell-cell interaction between macrophage and CADM1-transfected ED cells was not observed. We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 57 (1), 15-20, 2017
Japanese Society of Lymphoma Research