CD5-Positive Diffuse Large B Cell Lymphoma Infiltrating the Central Nervous System Presenting Guillain-Barré-Like Syndrome after Chemotherapy

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  • Machida Hisanori
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital
  • Shinohara Tsutomu
    Department of Clinical Investigation National Hospital Organization National Kochi Hospital
  • Hatakeyama Nobuo
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital
  • Okano Yoshio
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital
  • Nakano Mayuri
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital
  • Tobiume Makoto
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital
  • Naruse Keishi
    Division of Pathology National Hospital Organization National Kochi Hospital
  • Iwahara Yoshihito
    Division of Internal Medicine National Hospital Organization National Kochi Hospital
  • Ogushi Fumitaka
    Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

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  • CD5-Positive Diffuse Large B Cell Lymphoma Infiltrating the Central Nervous System Presenting Guillain-Barr^|^eacute;-Like Syndrome after Chemotherapy

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An 83-year-old woman was admitted to our hospital with abdominal pain. Examination revealed mediastinal lymphoadenopathy, hepatosplenomegaly, and infiltration of abnormal cells into the bone marrow with hemophagocytosis, and CD5-positive diffuse large B cell lymphoma was diagnosed. Chemotherapy was administered and progressive weakness of the limbs, resembling a Guillain-Barré-like syndrome, subsequently appeared. Cerebrospinal fluid examination indicated lymphoma cell infiltration. Although immune globulin and steroid therapies were not effective, intrathecal injection of methotrexate, predonisolone, and cytarabine improved these symptoms. Subsequent to chemotherapy, cell surface antigen changes were observed in the cerebrospinal fluid relative to those in bone marrow. [J Clin Exp Hematopathol 52(3) : 199-204, 2012]

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