Canine Primary Hypothyroidism and Apprication and Evaluation of Thyroid Function Tests

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  • HAYASAKI MINEO
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • OHISHI ISAMU
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • KOBAYASHI SHIGEO
    Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

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Other Title
  • 犬の原発性甲状腺機能低下症と甲状腺機能検査の応用と評価
  • イヌ ノ ゲンパツセイ キノウ テイカショウ ト コウジョウセン キノウ ケンサ ノ オウヨウ ト ヒョウカ
  • イヌ ノ ゲンパツセイ コウジョウセン キノウ テイカショウ ト コウジョウセ

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Abstract

Primary hypothyroidism was diagnosed in a 4-year-old golden retriever bitch with a disturbance in gait as a chief complaint. This bitch showed bilateral alopecia, hyperpigmentation, thicking and wrinkling of the skin, seborrhea, and myxedema-like edematous skin. Anemia, hypercholesteremia, and low values of serum thyroxine (0.4 μg/dl) and triiodothyronine-binding capacity index (0.88) were revealed. Serum protein-binding iodine was normal (2.8 μg/dl), as compared with that in 15 normal dogs (3.3±1.58 μg/dl). The values of these three thyroid function tests (T4, TBC index and PBI) showed no significant changes 24 hours after TSH (5-10 IU) stimulation, as compared with those before stimulation. In contrast, 5 normal dogs exhibited a significant increase (averaging 2.8 times) in PBI response to TSH stimulation. The spread of the iodine preparation on the skin surface boosted the PBI value (averaging 5.3 times).<BR>Treatment consisted of sodium L-tetraiodothyronine replacement at a dosage of 5-7.5 μg/kg, once a day. Clinical response was good to hormone therapy within 1 month. The atrophic thyroid gland was characterized by the severe destruction of follicles and replacement of most of the thyroid by fibrous connective tissue.

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