IN-VITRO ANTIMICROBIAL ACTIVITY OF RONIDAZOLE AGAINST <i>TREPONEMA HYODYSENTERIAE</i> AND THERAPEUTIC EFFICACY AGAINST EXPERIMENTAL SWINE DYSENTERY

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  • ロニダゾール: 豚赤痢トレポネーマに対する in vitro での抗菌活性および実験的豚赤痢に対する治療効果について

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The therapeutic efficacy of ronidazole, a synthetic antimicrobial agent of nitromidazole origin, against exrerimental swine dysentery in vivo was examined in the present study, along with its antimicrobial activity in vitro against Treponema hyodysenteriae. The results were described as follows.<br>1. In vitro study: The antimicrobial activity of ronidazole against isolates of T. hyodysenteriae was evaluated by the agar plate dilution method. The minimum inhibitory concentrations proved to be≤0.1μg/ml for five isolates used in the present study, showing its high antimicrobial activity.<br>2. In vivo study: The therapeutic efficacy of ronidazole against swine dysentery with SPF pigs intentionally infected by the pure culture of T. hyodysenteriae was evaluated by its administration for 3 successive days through water medication of ronidazole in a concentration of 0.003 or 0.006%. The results revealed that the affected pigs were recovered within 48 hours after initiating its administration and T. hyodysenteriae was eliminated from the feces. Normal weight gain and feed efficiency were also recovered. There was no case of onset of any symptom in the co-housing pigs during the experimental period of 10 days after terminating its administration, nor was there any recurrence of any symptoms from the recovered pigs.

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Details 詳細情報について

  • CRID
    1390282679683653632
  • NII Article ID
    130004184616
  • DOI
    10.14899/youton1964.17.173
  • ISSN
    21862567
    03888460
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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