Anthelmintic Effect of an Injectable Formulation of Praziquantel on Cestodes in Dogs and Cats

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  • 犬と猫の条虫に対するプラジクアンテル注射剤の駆虫効果
  • イヌ ト ネコ ノ ジョウチュウ ニ タイスル プラジクアンテル チュウシャザ

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An injectable formulation of praziquantel (Droncit® injectable, Bayer Japan Ltd., Tokyo, Japan) was evaluated for the anthelmintic effect on cestodes in dogs and cats. Twelve cats inoculated orally with 3 plerocercoids of Spirometra erinacei were divided into 4 groups of 3 animals each consisting of one nontreated control and 3 medicated groups. The medicated groups were injected subcutaneously and intramusculaly with the injectable formulation. One medicated group was administered orally with a tablet of praziquantel (Droncit® tablet, Bayer Japan Ltd., Tokyo, Japan). The dosage level was 30mg active ingredient per kg body weight which was determined 20days after infection. The anthelmintic was completely effective against S. erinacei in all medicated cats and there was no difference in the efficacy among the administrating methods. In subsequently executed clinical trials, subcutaneous and intramuscular injections of the injectable formulation completely eliminated cestodes from all treated animals: 36 dogs and 27 cats naturally infected with Dipylidium caninum, 2 dogs with Taenia sp. and 1 cat with Taenia taeniaeformis in a dose of 0.1 ml product (=5.68mg active ingredient) per kg body weight and 12 dogs and 22 cats with S. erinacei in a dose of 0.6ml (=34.08mg)/kg. These results confirm that subcutaneous and intramuscular injections of praziquantel resulted in the same complete efficacy as that by oral administration against cestodes in dogs and cats.

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