Pathological and Blood Biochemical Findings on Uric Acid Lithiasis of the Urinary Tract in Newborn Piglets

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  • 新生子豚の尿路系尿酸塩結石症の病理学的および血液生化学的所見
  • シンセイ コブタ ノ ニョウロケイ ニョウサンエン ケッセキショウ ノ ビョウ

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Abstract

With the objective of elucidating the etiology of uric acid calculi of the urinary tract in newborn piglets, 28 healthy newborn piglets and 21 weak newborn piglets, which were born in the winter months, were investigated.<BR>Clinically, yellow diarrhea was observed in 10 of the weak newborn piglets. Autopsy of these piglets revealed pale pink, fine granular calculi in the renal pyramids and papillae in 8 piglets, and abnormalities, such as petechial hemorrhage and edema in the kidneys, as well as discoloration of the liver, in 5 piglets. histopathological studies were conducted on the liver, kidney, sternal bone marrow, and spleen. Calculi were present in the tubular lumina without obstructing the tubules, and were identified as uric acid calculi by a staining of Saint-Hilaire method. However, the relationship between the calculi and the histopathological abnormalities could not be determined.<BR>A blood biochemical study on the weak piglets revealed a low value of serum albumin and high values of GOT, GPT, creatinine, BUN, uric acid, lactic acid, and inorganic phosphorus. In addition, one week after delivery, the serum total protein level and the hepatic uricase level were lower than normal levels.<BR>On the basis of the above findings, uric acid calculi of the urinary tract in weak newborn piglets which were born in the winter months is surmised to be induced by the combined action of 1) factors peculiar to newborn piglets, such as hepatic hypofunction, a low uricase level in the liver, acidosis, renal hypofunction, and increased catabolism of protein accompanying hypoalimentation, and 2) bad conditions for health, such as diarrhea and cold.

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