Four Cases of Generalized Lipofuscinosis in Cows

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  • OHFUJI Susumu
    Ubushi substation, Teshio branch of Hokkaido Rumoi Health Centre

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  • 乳牛の全身性リポフスチン沈着症の4例
  • ニュウギュウ ノ ゼンシンセイ リポフスチン チンチャクショウ ノ 4レイ

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Four Cases of Holstein-Friesian cows, 4 2/3 to 7 years old, were slaughtered due to unfavorable clinical diagnoses such as lumbar paralysis, pelvic trauma, and chronic necrotizing pododermatitis, and were diagnosed as generalized lipofuscinosis. In all cases, most of the skeletal, tongue, masseter and diaphragm muscles were grossly tinged with dark brown, and the cardiac muscle, liver, kidney, adrenal cortex, muscular layer of the small intestines and cerebral cortex were also affected with brown discoloration. Microscopy revealed a generalized intracytoplasmic deposition of fine or coarse granules, tinctorially identical to lipofuscin, which were PAS-positive, sudanophilic, acid fast, and yellowish-orange autofluorescent. The cardiac muscle fibers (1 case), diaphragm (3 cases), and intestines (all cases) had intracytoplasmic eosinophilic granules or hyaline droplets of various sizes up to 14μm in diameter. The diaphragmatic muscle fibers (3 cases) had central autophagic vacuoles. No glial reaction was seen around nerve cells containing lipofuscin pigments.

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