Ｃａｒｂｅｔｏｃｉｎ，　ＯｘｙｔｏｃｉｎおよびＰｒｏｓｔａｇｌａｎｄｉｎ　Ｆ２α投与後における豚の一般臨床所見の推移

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  • Effects of carbetocin, oxytocin, and prostaglandin F2.ALPHA. on clinical findings and blood characteristics in sows.

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The effects of carbetocin (a long-active oxytocin), oxytocin and prostaglandin F2α (PG) on clinical findings and blood characteristics were investigated with swine in this study. Six healthy post-weaning sows weighing 195 up to 300kg were given 0.2mg of carbetocin, 25IU of oxytocin, and 10mg of PG by intravenous injection on the first, second and third days, respectively. The check was made at 0, 30, 60, 90 and 120 minutes after each injection. Transient flush of skin, vomiting, urination and defecation were clearly noted since immediately after injection of PG, which lasted for approx. 30 minutes. However, no adverse effect upon the clinical findings was found out with the other two agents.<br>The heart rate of the sows in the group of oxytocin injection at 120 minutes after its injection significantly increased over the value at 0 minute after the injection. The body temperature fairly rose up after injection of any of the three tested agents, but no significant change was found out in the body temperature, pulse rate or respiration of any animal except the increase of heart rate at 120 minutes after injection of oxytocin.<br>The values of erythrocytic elements (RBC, Hb and Ht) demonstrated substantial variations, and significant rises were noted in the Hb values of the carbetocin and oxytocin groups. There were no significant changes in the leukocyte counts or total plasma protein values.

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