Investigation into the Conditions and Factors Associated with the Onset of Bovine Leukosis in Holstein Cows in Middle Hyogo Prefecture

TOMITA Keisuke, CYUZYO Masaki, KAMOMAE Yuka, YAZIMA Kazue, URAMOTO Kyoya, TAKESHIMA Shinnosuke, AIDA Yoko

doi:10.12935/jvma.66.109

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兵庫県中部でみられたホルスタイン種における牛白血病の病態及び発症要因の検討
産業動物臨床・家畜衛生関連部門兵庫県中部でみられたホルスタイン種における牛白血病の病態及び発症要因の検討
サンギョウドウブツリンショウ・カチクエイセイカンレンブモンヒョウゴケンチュウブデミラレタホルスタインシュニオケルギュウハッケツビョウノビョウタイオヨビハッショウヨウインノケントウ

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Abstract

We investigated the conditions and factors associated with the onset of bovine leukosis in 18 Holstein cows from July to November 2009. Physical examinations revealed abnormalities in 22% cows, while blood tests revealed abnormal lymphocytes in the peripheral blood of 57% cows. Histological examinations revealed diffuse, large cell lymphosarcoma in all cows. T-cell lymphoma was detected in a 29-month-old cow without bovine leukemia virus (BLV) infection, while B-cell lymphoma was observed in the remaining 17 cows aged ≥45 months with BLV genotype I. Immunohistochemical examinations detected p53 proteins in 29% of leukemic cows with a significant difference compared with that in the control. PCR analysis did not detect bovine immunodeficiency virus (BIV) in any cow. Bovine leukocyte antigen (BoLA) DRB3 allele 1501 was detected in 75% of leukemic cows; allelic frequency was 41% and there was a significant difference compared with that in the control. These findings suggest that nearly all cases of bovine leukosis in this study were enzootic bovine leukosis with BLV genotype I, that onset of bovine leukosis does not necessarily require BIV infection, and that p53 and BoLA-DRB3 alleles play some role in the onset of bovine leukosis.

Journal

Journal of the Japan Veterinary Medical Association

Journal of the Japan Veterinary Medical Association 66 (2), 109-114, 2013

Japan Veterinary Medical Association

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