ペントバルビタールナトリウム麻酔に対する抗バルビツール酸剤の応用

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書誌事項

タイトル別名
  • Application of Anti-barbiturate Agent to Anesthesia by Pentobarbital Sodium

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Dogs were anesthetized with pentobarbital sodium at a standard medicinal dose or a toxic dose by the intravenous route. They were examined for physiological functions with changes in respiration, heartbeat, electromyogram (of the musculus obliguus abdominis), electrocardiogram, and blood pressure as indicators for clinical findings. As a result, dogs administered with a toxic dose of the drug exhibited a remarkable inhibition of respiration, sinusal bradycardia, prolongation of the period of cardiac excitation, and other toxic symptoms of anesthesia. Some of them became fatal due to delay in waking from anesthesia.<BR>Then an anti-barbiturate agent (β, β-methylethylglutarimide) was administered to cases of anestheticanesthetic toxication caused by overdosing of that drug. As a result, the clinical signs of anesthetic toxication were much improved and the time of waking from anesthesia was accelerated. The therapeutic dose of the agent depends on the depth of anesthesia. It may be effective to administer about 10mg/kg of the agent to a dog which has received 40mg/kg of pentobarbital sodium. In this case, the dog begins to show voluntary movements of the muscles around the eyelids and cutaneous muscles and the extension of the four limbs while the agent is being injected intravenously. Therefore, it is recommended that the dosing of the agent be carried out with the appearance of these clinical signs as standards.

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