Pharmacokinetic Estimation of Sulfamonomethoxine Residue at the Site of Intramuscular Injection

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  • ウシ・ブタにおけるスルファモノメトキシン筋注時の注射部位残留量の薬剤動態学による予測
  • ウシ ブタ ニ オケル スルファモノメトキシン キンチュウジ ノ チュウシャ

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Abstract

Sulfamonomethoxine (SMX) residues at the site of intramuscular (i.m.) injection in cattle and swine were pharmacokinetically estimated from blood concentration-time curves. Availability of SMX after i. m. injection was evaluated to be about 1 in both animal species. The rate of absorption expressed as half life was estimated to be 13.8 minutes for cattle and 26.6 minutes for swine. These results suggested that the residual concentration of SMX at the site of i.m. injection might be below 0.1 ppm within 10hours.

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