A Rare Case of Mediastinal T-Cell Lymphoma in a Juvenile Dog

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  • YAMAZAKI Hiroki
    Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University
  • KAWABATA Takahiro
    Kawabata Animal Hospital
  • SAWA Mariko
    Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University
  • LAI Yu-Chang
    Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University
  • YABUKI Akira
    Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University
  • MIURA Naoki
    Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University

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  • 縦隔型T細胞性リンパ腫を呈した若齢犬の1例
  • ジュウカクガタ Tサイボウセイ リンパシュ オ テイシタ ジャクレイケン ノ 1レイ

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Abstract

Mediastinal mass and hepatomegaly were detected by computed tomography in a 10-month-old Miniature Dachshund presenting with dyspnea. The dog was diagnosed as mediastinal T-cell lymphoma with liver invasion by cytological and clonality examination. Multidrug therapy (UW-25) was not effective for the dog. As a second-line therapy, a combination treatment of toceranib phosphate and CCNU was performed based on the expression profiling of multidrug resistance genes and angiogenic genes by qRT-PCR analysis, resulting in an improved condition. However, the dog died from dyspnea at 36 days after first examination. T-cell lymphoma was confirmed by necropsy.

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