Safety and Immunogenicity on Pregnant Sowsofan Attenuated Strain of Porcine Parvovirus after Serial Passages at Low Temperature

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  • 豚パルボウイルス低温順化弱毒株の妊娠豚における安全性と免疫原性
  • ブタ パルボ ウイルス テイ オンジュンカ ジャクドクカブ ノ ニンシン ブタ

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Abstract

When a pregnant sow was inoculated subcutaneously with 106.0TCID50/2ml of the HT-SK-C strain at 74 days of pregnancy, it showed no clinical signs and the virus was not recovered from pharynx, larynx, nasal cavity or rectum. Viremia was not obscrvcd. At 104 days of pregnancy, it was sacrificedfor autopsy. An atempt was made to recover the virus from its fetus and their accessary organs. It had 13 fetuses, which were normal macroscopically. The inoculated virus was not recovered from the respiratory organs or rectum of 7 fetuses tested.<BR>tested. Apregnant sow was inoculated subcutaneously with 106.0TCID50/2ml of the HT-SK-C strain at 42 days of pregnancy. It was challenged intravenously with 105.0TCID50/5ml of thc virulent strain at 66 days of pregnancy along with an uninoculated control pregnant sow. At 46 days after challenge (112 days of pregnancy), these pregnant sows were sacrified fbr autpsy The inoculated sow harborcd l5 fbtuses, which were all alive with no clinical signs. No challenge vrius was recovered from 8 fbtuses examined. The cohabiting control pregnant sow harbored l l fbtuses, of which 7 were hormal, 3 macerated and one was mummifbrm. The challenge virus was detected from tested organs. HI antibody titers of 5 gilts were 1: 40-1: 320 at 14 weeks after inoculation with 106.0TCID50/2ml of the HT--SK-C strain.

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