Case study of equine leptospirosis associated with renal failure

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  • 腎機能不全を主徴とした馬のレプトスピラ症
  • ジンキノウ フゼン オ シュチョウ ト シタ ウマ ノ レプトスピラショウ

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A one-year-old thoroughbred that, immediately following long-distance shipping, had contracted a fever and subsequent renal failure was admitted to our Veterinary Teaching Hospital 21 days after having been shipped. In addition to important clinical laboratory findings such as congested visible mucous membrane, leukocytosis, and azotemia, a gene fragment specific to leptospira interrogans sensu lato was evidently amplified by the culture media from urine deposit and blood. Although the white cell blood count and blood urea nitrogen were normalized around the 11th and 21st days following fluid therapy (75ml/kg/day) and antibiotics administration (cefazolin sodium 50mg/kg/day), polyuria and polydipsia were persistent. Hypercalcemia and hypophosphatemia and an increased ratio of BUN to creatinine (＞10) also developed, and consequently the horse was euthanized on the 33rd day of hospitalization. The necropsy confirmed enlargement of both kidneys and the hyperplasia of the cortex. A case report of equine leptospirosis associated with renal failure suggests the need for a longitudinal epidemiological survey of leptospira interrogans serovars in Japanese horses.

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