Histological Evaluation of Apatite Cement Containing Atelocollagen

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  • TAKECHI Masaaki
    Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University
  • MIYAMOTO Youji
    Division of Dentistry and Oral Surgery, Akita University Hospital
  • ISHIKAWA Kunio
    Department of Biomaterials, Faculty of Dental Science, Kyushu University
  • MOMOTA Yukihiro
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • YUASA Tetsuya
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TATEHARA Seiko
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • TAKANO Hideyuki
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • MINAMIGUCHI Shiho
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • NAGAYAMA Masaru
    Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School

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説明

Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC.

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