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Relation of a Decrease in Arterial Compliance to ST Segment Depression on Exercise Electrocardiograms in Patients with Hypertension.
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- Ohtsuka Sadanori
- the Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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- Kakihana Masaaki
- the Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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- Watanabe Hideki
- the Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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- Ajisaka Ryuichi
- the Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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- Sugishita Yasuro
- the Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba
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Description
Decreased arterial compliance (ACo) and increased arterial resistance are the major alterations of arterial function in patients with hypertension. The influence of decreased ACo on the heart was investigated in patients with hypertension. Patients with a systolic blood pressure of >140mmHg, a diastolic blood pressure of >90mmHg, or both, who had normal coronary arteriograms were enrolled. These patients were divided into two groups according to the value of ACo: Group I, patients with ACo_??_0.9 ml/mmHg (n=15); and Group II, patients with ACo<0.9ml/mmHg (n=13). There were no significant differences in arterial resistance, age, gender, and body surface area between the groups. Echocardiographic, hemodynamic, and exercise stress test variables were compared between the groups. There were no differences between the groups in left ventricular (LV) wall thickness and volume, cardiac output, LV end-diastolic pressure, and LV ejection fraction. However, pulse pressure was higher in Group II than in Group I. Ergometer exercise stress testing revealed that, although exercise duration and the peak rate-pressure product were similar in the two groups, ST segment depression of _??_1.0mm on the exercise electrocardiograms was induced more frequently in Group II than in Group I (92% vs. 27%, p <0.001). Thus, the decrease in ACo in patients with hypertension may not significantly affect LV wall thickness, volume, or ejection fraction; however, it may increase pulse pressure and may adversely affect coronary circulation, as suggested by the ST segment depression on exercise electrocardiograms. (Hypertens Res 1997; 20: 11-16)
Journal
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- Hypertension Research
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Hypertension Research 20 (1), 11-16, 1997
The Japanese Society of Hypertension
