Incidence of ventricular premature contractions induced by thiopental sodium in dogs.

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  • 犬におけるチオペンタールナトリウム投与による心室性期外収縮の発生率

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Incidence of ventricular premature contractions (VPC) induced by thiopental sodium alone or thiopental sodium with premedicant administrations were evaluated utilizing 78 beagle dogs. Twenty four out of 78 beagles (30.8%) produced VPC when 25 mg/kg of thiopental sodium were slowly (60 sec) administered intravenously. Twenty four beagles that produced VPC were re-evaluated by an administration of thiopental sodium, which resulted in the increased incidence of VPC in 19 dogs (79.2%) . Fifteen beagles among 19 were administered thiopental sodium until eyelid closure reflex disappeared with combinations of droperidol, propionylpromazine and diazepam under the influence of atropine sulphate. A slight decrease in the incidence of VPC was observed with these premedicants administrations. It is probably due to the decreased doses of thiopental sodium administration.

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