Squamous cell carcinoma of the dorsum of tongue thought to be derived from Plummer-Vinson syndrome

DOI 3 Citations Open Access
  • HAYASHI Yasushi
    Department of Oral Surgery, Nagoya University School of Medicine
  • YAMBE Makoto
    Department of Oral Surgery, Nagoya University School of Medicine
  • SHINODA Tetsurou
    Department of Oral Surgery, Nagoya University School of Medicine
  • GOTO Yasuyuki
    Department of Oral Surgery, Nagoya University School of Medicine
  • TAKEUCHI Yusuke
    Department of Oral Surgery, Nagoya University School of Medicine
  • TOHNAI Iwai
    Department of Oral Surgery, Nagoya University School of Medicine
  • MIZUTANI Hideki
    Department of Oral Surgery, Nagoya University School of Medicine
  • KANEDA Toshio
    Department of Oral Surgery, Nagoya University School of Medicine
  • SAITO Hiroshi
    Department of internal medicine, The City of Tsushima Hospital

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Other Title
  • Plummer-Vinson 症候群の舌炎から移行したと思われる舌背部扁平上皮癌
  • case of report

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The Plummer-Vinson syndrome is payed attention as the precancerous lesion of the hypopharyngeal and the cervical legion of esophagus, but that of tongue is uncommon. We report here the squamous cell carcinoma of the dorsum of tongue seems to be derived from the glossitis of Plummer-Vinson syndrome. The case was a female, fifty-four years old, who visited our department because of the lingual pain in 1985. After the examination of blood and isotope labeling, she was diagnosed as having Iron deficiency with both anaemia and tissue damage (IDAD). The main treatments were alimentary therapy and intravenous administration of iron. After the treatment the symptoms except atrophy the papillae lingualis atrophy were almost improved. So, after she was followed up in the city hospital. Six months laterfrom the end of the treatment, as she was pointed out the lingual tumor, she visited our department again in 1987. The induration of 35×25×5mm in size was palpable at the same site of dorsum of tongue as previous lesion. The result of biopsy was welldifferentiated carcinoma. After chemoterapy, irradiation and hyperthermia, biopsy repeated several times proved to be no malignancy. So she is being followed up now.<br>Not only Plummer-Vinson syndrome but also IDAD and the iron deficiency with tissue damage without anaemia (IDD) may be the precancerous lesion in view of the fact the glossitis due to iron deficiency preceeded cancer in this case. Therefore we think that the suitable diagnosis, early treatment of IDAD and IDD are very important.

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