抜歯後とう痛に対するＹＭ１７７の用量反応性ならびに至適投与量に関する検討

DOI

書誌事項

タイトル別名
  • A study of the dose-response of YM177 for treatment of postsurgical dental pain.

抄録

A multicenter, double-blind, placebo-controlled, parallel group comparative study was conducted to demonstrate the dose-response relationship of YM177, and to determine its recommended dose. YM177 is a selective inhibitor of COX-2, Which is associated with pain following the extraction of mandibular-impacted wisdom teeth. Global improvement rates and patients' subjective impressions were established as primary parameters. Five doses of YM177 (25, 50, 100, 200, and 400 mg), plus a placebo, were studied. Global improvement rates and subjective efficacy rates, as reported by patients, demonstrated significant differences when compared with placebo in patients receiving doses of 25 mg or more. Moreover, among the five YM177 dose groups, we found greater improvement and efficacy rates with increasing doses. In addition, the YM177 200 mg group, and the YM177 400 mg group, showed improvement rates of 70% or greater in all primary parameters of evaluation, demonstrating significant efficacy of YM177 as a therapeutic drug. As to the drug's safety, no serious adverse events developed in any patient of the YM177 dosage groups.<BR>It is therefore considered that both 200 mg and 400 mg are clinically effective doses, in line with the definition of “dose selection” pre-determined in this study.

収録刊行物

  • 歯科薬物療法

    歯科薬物療法 20 (3), 154-172, 2001

    日本歯科薬物療法学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679704600704
  • NII論文ID
    130004040493
  • DOI
    10.11263/jsotp1982.20.154
  • ISSN
    18844928
    02881012
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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