Evaluation of new stage classification for nasopharyngeal carcinoma.

DOI 13 References Open Access
  • TOKUMARU Yutaka
    Department of Otolaryngology, School of Medicine, Keio University
  • FUJII Masato
    Department of Otolaryngology, School of Medicine, Keio University
  • OHNO Yoshihiro
    Department of Otolaryngology, School of Medicine, Keio University
  • IMANISHI Yorihisa
    Department of Otolaryngology, School of Medicine, Keio University
  • KANKE Minoru
    Department of Otolaryngology, School of Medicine, Keio University
  • TOMITA Toshiki
    Department of Otolaryngology, School of Medicine, Keio University
  • SHIGEMATSU Naoyuki
    Department of Radiology, School of Medicine, Keio University
  • KUBO Atsushi
    Department of Radiology, School of Medicine, Keio University
  • KANZAKI Jin
    Department of Otolaryngology, School of Medicine, Keio University
  • INUYAMA Yukio
    Department of Otolaryngology, School of Medicine, Hokkaido University

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Other Title
  • 上咽頭癌における新TNM分類の検討

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The new stage classification, which appeared in the fifth edition of the UICC TNM Classification of Malignant Tumours for nasopharyngeal carcinoma (NPC), was evaluated. The new classification was applied retrospectively to 69 patients with nasopharyngeal squamous cell carcinoma treated at the Keio University Hospital in 1980-1996. The results were also compared with those obtained by the former classification for NPC in the fourth edition of the TNM Classification of Malignant Tumours. In the stage grouping, the new classification classified 13.0% of patients in stage I, 36.2% stage II, 23.2% stage III and 27.5% stage IV. The new classification separated the patients more equally than the former classification, which classified 68.1% of patients in stage IV. Down staging was observed in 45 cases. With the new classification, the 5-year overall survival rates for stage I, II, III and IV were 87.5%, 77.8%, 50.0% and 47.4% respectively. Significant differences were observed among these stages (p<0.01). The new classification seemed to be more prognostically useful than the former classification to treat NPC patients appropriately.

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