Clinical evaluation of cefteram pivoxil in the oral infections.

DOI 1 Citations
  • SASAKI JIRO
    Department of Oral Surgery, School of Medicine, Tokai University
  • KANEKO AKIHIRO
    Department of Oral Surgery, School of Medicine, Tokai University
  • SHIIKI KAZUO
    Department of Dentistry and Oral Surgery, Iwaki Kyoritsu General Hospital
  • YAMANE NOBUO
    Department of Dentistry and Oral Surgery, Iwaki Kyoritsu General Hospital
  • SAKAMOTO HARUO
    Department of Dentistry and Oral Surgery, Ashikaga Red Cross Hospital
  • MORISHIMA TAKASHI
    Department of Dentistry and Oral Surgery, Ashikaga Red Cross Hospital
  • SATOH TAZUKO
    The Nippon Dental University, School of Dentistry at Tokyo, Department of Oral and Maxillofacial Surgery 1
  • MICHI KEN-ICHI
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • OHNO KOSUKE
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • OSONE YOU
    Department of Dentistry, Tokyo Metropolitan Bokuto General Hospital
  • MIKAMI SHIN
    Department of Dentistry, Tokyo Metropolitan Bokuto General Hospital
  • KONNAI TOSHIKATSU
    Department of Dentistry and Oral Surgery, National Tosei Hospital
  • YAMAMOTO TADASHI
    Department of Dentistry and Oral Surgery, Toyohashi Municipal Hospital
  • KANOH YOSHINORI
    Department of Dentistry and Oral Surgery, Toyohashi Municipal Hospital
  • HATTORI TAKANORI
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
  • NARITA TAKANORI
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
  • SUGIMURA MASAHITO
    Department of Oral Surgery, Nara Medical College
  • UEMURA KAZUYOSHI
    Department of Oral Surgery, Nara Medical College
  • FUJII NOBUO
    Department of Oral Surgery, Okinawa Prefectual Chubu Hospital
  • DEGUCHI KOH-ICHI
    Laboratory Section, Tokyo Clinical Research Center

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Other Title
  • 口腔外科領域感染症に対するセフテラムピボキシルの臨床的検討

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To evaluate the clinical efficacy, safety and utility of Cefteram pivoxil (CFTM-PI) in treating odontogenic infections such as periodontal infection, pericoronitis and osteitis of jaw, we carried out clinical study with 11 institutes. CFTM-PI was administered to 208 patients for odontogenic infections and the dosage was 300 mg/day or 600 mg/day divided into three doses. The following results were obtained.<BR>1) Committee evaluation of the clinical efficacy gave efficacy rate of 88.1% for all cases. The committee's efficacy rates by diagnosis were 90.2%, 91.1% and 85.1% for periodontal infection, pericoronitis and osteitis of jaw, respectively. The efficacy rate of the 300mg group and 600mg group, as judged by committee were 84.0% and 89.4%, respectively.<BR>2) The attending physicians gave efficacy rate of 83.3% for all cases.<BR>3) By needle aspiration to avoid contaminating from the oral floras, 161 strains were isolated from closed abscesses of 91 patients. The isolation rates of aerobic gram-positive bacteria, aerobic gramnegative bacteria, anaerobic gram-positive bacteria and anaerobic gram-negative bacteria were 43.5% (70/161 strains), 2.5% (4/161), 45.3% (73/161) and 8.7% (14/161), respectively. The bacteriological response was“eradication of bacteria”in 52 cases, “unchange of bacteria”in one, “unknown of bacteria”in 16 and unknown in 22. The eradication rate judged by committee was 75.4%.<BR>4) Side effects were noted in 2 (1.0%) out of 207 cases and the symptom was diarrhea for one and abdominal pain for another. These symptoms were not serious in degree. Abnormal changes in laboratory findings were found in 8 patients and main symptom of them was elevation of transaminase.

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