Chemosensitivity, histolgic differentiation and DNA ploidy in human head and neck tumors.

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  • 頭頚部癌の薬剤感受性と病理組織分化度，細胞異型度との関連について

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The chemosensitivity of 158 human head and neck tumors was examined using in vitro succinate dehydrogenase inhibition (SDI) test. Histologically, malignant lymphoma and squamous cell carcinoma were most sensitive to examined five antitumor agents (adriamycin, cisplatin, carboquone, 5-fluoruracil, mitomycin C). In head and neck squamous cell carcinomas, cellular DNA content was also examined and the chemosensitivity and ploidy status were compared with histologic differentiation. The average decrease of enzyme activity in the poorly differentiated squamous cell carcinomas was significantly greater than than that of well and moderately differentiated squamous cell carcinomas. DNA aneuploidy was detected in 45 of 63 (71%) examined tumors. As compared to almost half of the laryngeal and pharyngeal tumors with an aneuploid pattern, every maxillary cancer and 17 out of 19 oral cavity cancers were aneuploid.<br>Poorly differentiated carcinomas with DNA aneuploidy tend to show the highest chemosensitivity. These results indicate that simultaneous survey of the chemosensitivity and DNA ploidy status will aid in selecting effective antitumor agents against human head and neck cancers.

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