PROGNOSIS AND THERAPEUTIC STRATEGY FOR PATIENTS WITH DISTANT METASTASIS OF PAPILLARY THYROID CARCINOMA

DOI 5 Citations 13 References

Bibliographic Information

Other Title
  • 甲状腺乳頭癌における遠隔転移―予後の予測と治療方針
  • 予後の予測と治療方針

Search this article

Description

Although distant metastasis (M) represents the most important prognostic factor for cancer-specific death of patients with papillary thyroid carcinoma (PTC), some patients display extremely slow-growing M. Correctly predicting prognosis is extremely difficult in such cases.<br>Of 604 patients with PTC at our institution (1976-1998, excluding microcarcinoma), 32 patients (5.3%) displayed M at presentation and 26 patients (4.3%) developed M after primary surgery. Of the 58 total patients with M, 28 (48.3%) died of the disease. Of these, 5 died from local invasion of PTC or complications associated with treatment. Conversely, 7 patients with M displayed complete response to radio-iodine therapy and/or resection of metastatic lesions.<br>Patients displaying rapid progression of M (n=24) were compared with patients (n=24) in whom M demonstrated no change over 5-year observation. Age (<50 years old), smaller M (<2-cm diameter), lung metastasis without other M, and primary tumor predominantly comprising well-differentiated components were associated with significantly improved survival.<br>In conclusion, local control of PTC is significant even in patients with M, particularly when M appears to be slow-growing.

Journal

Citations (5)*help

See more

References(13)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top