Clinical effects of benzydamine hydrochloride gargle preparation (NIK-237) on oral mucosal lesions. A well-controlled comparative study with placebo.

DOI
  • MICHI KEN-ICHI
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • AKIZUKI HIROMICHI
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • TAKAI HIROSHI
    First Department of Oro-Maxillo-Facial Surgery, Tohoku Dental University
  • TAKEMOTO YASUSHI
    First Department of Oro-Maxillo-Facial Surgery, Tohoku Dental University
  • UCHIDA YASUNOBU
    Department of Oral Surgery, Tokyo Medical College
  • NARITA YOSHIHIRO
    Department of Oral Surgery, Tokyo Medical College
  • HASHIMOTO KENJI
    The First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University
  • TANAKA NOBUYUKI
    The First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University
  • SATO HIROSHI
    Second Department of Oral Surgery, Nihon University School of Dentistry
  • TERAKADO MASAAKI
    Second Department of Oral Surgery, Nihon University School of Dentistry
  • HISANO YOSHIO
    The Nippon Dental University, School of Dentistry at Tokyo, Department of Oral and Maxillofacial Surgery I
  • OSHIMA YASUHIDE
    The Nippon Dental University, School of Dentistry at Tokyo, Department of Oral and Maxillofacial Surgery I
  • NOMA HIROYASU
    First Department of Oral and Maxillofacial Surgery, Tokyo Dental College
  • SHIBAHARA TAKAHIKO
    First Department of Oral and Maxillofacial Surgery, Tokyo Dental College
  • NAGUMO MASAO
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • SAKURADA SHIGEYO
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
  • ISHIBASHI KATSUNORI
    Second Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University
  • KIMORI ETSURO
    Second Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University
  • SASAKI JIRO
    Department of Oral Surgery, School of Medicine, Tokai University
  • UEMATSU MASATAKA
    Department of Oral Surgery, School of Medicine, Tokai University
  • OGAWA NOBUYA
    Department of Pharmacology, Ehime University, School of Medicine

Bibliographic Information

Other Title
  • 口腔粘膜疾患に対する含そう用塩酸ベンジダミン溶液（ＮＩＫ‐２３７）の臨床試験　　Ｗｅｌｌ　ｃｏｎｔｒｏｌｌｅｄ　ｓｔｕｄｙによるｐｌａｃｅｂｏとの比較
  • A well-controlled comparative study with placebo
  • ―Well controlled study によるplaceboとの比較―

Description

The analgesic effects and safety of a 0.15% benzydamine gargle preparation (NIK-237) on aphtha and lichen planus lesions were investigated in a controlled study using placebo. The clinical effects of each drug were evaluated in 149 patients (NIK-237-treated group: 75, placebo-treated group : 74), and the following results were obtained.<BR>1) Analgesic effect according to the judgment of the physician in charge : The NIK-237-treated group was superior, with a significant difference being observed (p<0.05) compared to the placebo-treated group.<BR>2) Analgesic effect by scoring: The NIK-237-treated group was superior, with a significant difference being observed (p<0.05) compared to the placebo-treated group.<BR>3) Overall safety rating : Both groups were judged to produce no side effects.<BR>4) Usefulness : The NIK-237-treated group was superior, with a significant difference being observed (p<0.05) compared to the placebo-treated group.<BR>5) Improvement rating of spontaneous pain with time : The NIK-237-treated group was superior (p<0.05) or tended to be superior (p<0.1) to that of the placebo-treated group 15, 60 and 120 minutes after administration of the drugs.<BR>6) Effect on pain at the time of eating : The NIK-237-treated group tended to be superior (p<0.1) to that of the placebo-treated group.<BR>From the above results, it is concluded that NIK-237 is highly useful for the treatment of oral mucosal diseases.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390282679710983552
  • NII Article ID
    130004040640
  • DOI
    10.11263/jsotp1982.6.207
  • ISSN
    18844928
    02881012
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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