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Analysis of the stability and microbiological safety of aznol saline gargle in hospital preparations widely used for the treatment of oral cancer patients with oral mucositis
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- USHIYAMA MINA
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital
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- IKEDA RYUJI
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital
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- NITTA TETSUYA
- Department of Oral and Maxillofacial Surgery, Fukui Prefectural Hospital
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- TAZITSU YUSUKE
- Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- MIYAWAKI AKIHIKO
- Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University
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- YAMAGUCHI TATSUYA
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital
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- SHIMODOUZONO YOSHIHIRO
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital
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- USHINOHAMA KAZAMI
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital
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- MATSUI RYUTARO
- Department of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Medical and Dental Sciences, Kagoshima University
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- SUGIHARA KAZUMASA
- Department of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Medical and Dental Sciences, Kagoshima University
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- NAKAMURA NORIFUMI
- Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University
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- YAMADA KATSUSHI
- Department of Clinical Pharmacy and Pharmacology, Kagoshima University Hospital Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
Bibliographic Information
- Other Title
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- 口腔癌治療時に汎用される院内製剤アズノール含漱水の安定性と細菌学的検討
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Description
In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.<BR>We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.
Journal
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- ORAL THERAPEUTICS AND PHARMACOLOGY
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ORAL THERAPEUTICS AND PHARMACOLOGY 27 (3), 143-150, 2008
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
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Keywords
Details 詳細情報について
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- CRID
- 1390282679711925376
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- NII Article ID
- 130004040560
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- ISSN
- 18844928
- 02881012
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed