麻酔前投薬として用いたメキサゾラムの効果　　二重盲検法によるジアゼパム，プラセボとの比較

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  • The effects of mexazolam as a premedication. A comparative study with diazepam and placebo, using the double blind method.
  • A comparative study with diazepam and placebo, using the double blind method
  • ―二重盲検法によるジアゼパム, プラセボとの比較―

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The purpose of this study was to determine the effects of mexazolam when used as a premedication for oral administration. Patients (ASA I-II) were given elective oral surgery under general anesthesia or intravenous sedation, and mexazolam was used in a double blind test with diazepam and an inert placebo.<BR>Psychoneurological symptoms such as anxiety, sleeplessness and so on, were determined by questionnaires, and physical symptoms such as blood pressure, pulse rate and respiratory rate, were checked.<BR>Doses were administered to the 4 groups as follows : 2 or 3 mg to the mexazolam group and 10 mg to the diazepam and placebo group. These doses were administered at 9 o'clock the night before the operation and again 2.5 h prior to induction. Those patients scheduled for afternoon operations were also given doses 6.5 h before induction. The results were as follows<BR>1) In the doses administered, the sedative effects of mexazolam were the same as those of diazepam.<BR>2) The administered dosage of mexazolam tended to have a longer lasting effect than diazepam.<BR>3) The patients to whom mexazolam was administered showed no significant changes in physical symptoms.<BR>4) A dose of 3 mg of mexazolam as a premedication was shown to be more effective than 2 mg.<BR>These results suggested that mexazolam could be used effectively as a premedication.

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