Endoscopic Endonasal Resection of Olfactory Neuroblastomas: Our Experience

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  • Nakagawa Takayuki
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University
  • Kodama Satoru
    Department of Otorhinolaryngology and Head & Neck Surgery, Faculty of Medicine, Oita University
  • Kobayashi Masayoshi
    Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Mie University
  • Sakamoto Tatsunori
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University
  • Ogino-Nishimura Eriko
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University
  • Ito Juichi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University

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  • 嗅神経芽細胞腫に対する内視鏡下経鼻手術―その術式の検討

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The objective of this study was to establish a standard surgical procedure for endoscopic endonasal resection of olfactory neuroblastomas for future prospective clinical studies. We retrospectively reviewed 5 patients (4 males, 1 female) who underwent primary endoscopic endonasal resection of olfactory neuroblastomas. Of these, the Dulguerov stage at presentation was T1 in 2 patients (Kadish A and B in 1 each) and T2 (Kadish C) in 3 patients. The endoscopic endonasal surgery involved the resection of the middle and superior turbinates, cribrioform plate, ethmoidal fovea and olfactory fila with the intraoperative histological analyses of the margins. The main parameters compared were margin assessment, prognosis, preservation of olfaction, and complications. In one T2 case, tumor cells were identified in the margins of the olfactory fila, while resection with negative margins was achieved in the other 4 cases. No recurrence was found during observation periods ranging from 12 to 51 months (median: 25 months). Olfaction was maintained in 3 patients. No postoperative complications were identified. These findings indicated that more precise studies of intraoperative margin in the olfactory fila and dura matter are required for T2 patients.<br>

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