Coblation for Epistaxis in Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia), Including Suspected Cases

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  • Akazawa Hitoshi
    Department of Otorhinolaryngology, Ikeda Municipal Hospital Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Maeda Yohei
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Okazaki Suzuyo
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Hayama Masaki
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Takeda Kazuya
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Tsuda Takeshi
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Shikina Takashi
    Department of Otorhinolaryngology, Ikeda Municipal Hospital Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Inohara Hidenori
    Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine

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  • オスラー病（疑診例を含む）に伴う鼻出血に対するコブレーションシステムの使用経験

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<p>Osler-Weber-Rendu (OWR) disease, also known as hereditary hemorrhagic telangiectasia (HHT), is inherited in an autosomal dominant manner. The syndrome is characterized by mucocutaneous telangiectasias and multiorgan arteriovascular malformations (AVMs).</p><p>OWR disease presents as epistaxis, paradoxical cerebral embolism, and gastrointestinal hemorrhage. Epistaxis affects more than 90% of patients with OWR disease. Laser photocoagulation is a common surgical treatment. However, recent reports have suggested coblation as a treatment for epistaxis in OWR disease. A coblation system uses low-temperature bipolar radiofrequency ablation, which decreases thermal damage to surrounding tissues. In recent years, the epistaxis severity score has become the standard evaluation for severity of epistaxis in patients with OWR disease. In this study, we examined Epistaxis severity score in patients with OWR disease including suspected cases, treated with coblation for refractory epistaxis (12 cases, 6 patients.) We also evaluated Epistaxis severity score in cases with no missing data (10 cases). Epistaxis severity score in patients was found to be significantly lower 2 weeks and 2 months after coblation compared to before the procedure. These results suggest that coblation may be a reasonable alternative for refractory epistaxis in patients with OWR disease.</p>

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