A Case of Drug Induced Lung Injury Considered to Be Caused by a Supplement "Nin-niku Ran-ou (Garlic and Egg Yolk) "

DOI
  • Suzuki Shintaro
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
  • Tanaka Akihiko
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Kishino-Oki Yasunari
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Murata Yasunori
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Kusumoto Sojiro
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Ishida Hiroo
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Ando Koichi
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Shirai Takao
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Ohnishi Tsukasa
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Sagara Hironori
    Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine
  • Takimoto Masafumi
    Department of Pathology and Laboratory Medicine, Showa University School of Medicine

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Other Title
  • 「にんにく卵黄」による薬剤性肺障害と考えられた1例

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Description

Background. Many types of health foods are sold all over the world. A considerable number of patients take them together with their medication. In Japan, garlic and egg yolk supplements are frequently advertised, and are purchased by numerous customers. Case. A male patient aged 69 years had been taking garlic and egg yolk supplements for 4 years. He complained of shortness of breath and dry cough that lasted for a couple of weeks. Subsequently, he went to a hospital and was diagnosed with treatment-resistant pneumonia. The patient was treated with antibiotics and corticosteroids, but his symptoms did not improve. Consequently, he was transferred to our hospital. A chest plain computed tomography scan showed ground glass opacity in the bilateral middle to lower field. Bronchoalveolar lavage showed lymphocyte predominant infiltration. A specimen of transbronchial lung biopsy showed mild lymphocytic inflammation and mild organizing pneumonia. After the patient stopped taking garlic and egg yolk supplements, his symptoms improved quickly. A lymphocyte stimulating test using the same merchandise showed a positive result. Therefore, we considered garlic and egg yolk supplements might be a cause of the lung disorder in this case. Conclusion. Asking patients their histories of taking health foods and dietary supplements can lead to a diagnosis of lung injury.

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