A Case of Drug-induced Eosinophilic Pneumonia after Radiotherapy for Breast Cancer

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  • 薬剤性好酸球性肺炎の1例 : 乳癌に対する放射線照射後に出現した肺野病変

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A 59-year-old woman had fever, headache and general fatigue 3 months after left breast irradiation following conservative surgery for breast cancer. On admission, a chest radiograph showed bilateral pulmonary infiltrates in the middle lung field. CT scans revealed patchy consolidation with air bronchogram and ground glass attenuation areas surrounding the consolidation in bilateral lower lobes. These findings suggested BOOP. Analysis of bronchoalveolar lavage fluid showed markedly increased number of lymphocytes and eosinophils. On the other hand, drug lymphocyte stimulation test was positive for some nonsteroidal anti-inflammatory drugs, which the patient tended to overuse. Although, possibility of pneumonitis related to radiation therapy could not be denied, these opacities improved completely after stopping all drugs. Thus the final diagnosis of drug-induced eosinophilic pneumonia was made.

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