A Case of Endobronchial Granular Cell Tumor (GCT)

DOI 4 Citations 10 References
  • Sakurai Takayuki
    Department of Internal Medicine, Funabashi Municipal Medical Center:Department of Respirology, Seirei Hamamatsu Hospital
  • Nakamura Sukeyuki
    Department of Internal Medicine, Funabashi Municipal Medical Center
  • Kinoshita Koumei
    Department of Thoracic Surgery, Funabashi Municipal Medical Center
  • Nomoto Yasushi
    Department of Thoracic Surgery, Funabashi Municipal Medical Center

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Other Title
  • 気管支顆粒細胞腫の1例と本邦報告例57例の臨床的検討

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Background. Endobronchial granular cell tumor (GCT) is rare. Only 57 cases have been reported in Japan. Case. An abnormal shadow was pointed out on a chest X-ray film taken during regular treatment for bronchial asthma in a 62-year-old woman. We found a 10-mm in diameter nodular lesion in her left hilum with consolidation in left S^3 by CT scanning. Bronchofiberscopy revealed a nodular lesion with a granular surface at the orifice of left B^3. The biopsy specimen contained many cells with a low N/C ratio and which were positive for anti S-100 and anti NSE antibody. We made a diagnosis of GCT and resected the left upper lobe. Although the origin of GCT is still unknown, it has been suggested that GCT is derived from Schwann cell, because many GCT cases are positive for anti S-100 antibody in Japan. Almost all GCT cases in Japan occurred in lobar or larger bronchi, but the real pathogenesis is unknown. Conclusion. We reported a case of endobronchial GCT. We examined this case and other such cases reported in Japan, and it is suggested that GCT is derived from Schwann cell of peripheral nerves.

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