A Case of Follicular Lymphoma Diagnosed by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)

DOI
  • Minemura Hiroyuki
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Yokouchi Hiroshi
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Hirai Ken-ichiro
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Sekine Satoko
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Oshima Kengo
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Sato Suguru
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Kanazawa Kenya
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Tanino Yoshinori
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Ishida Takashi
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine:Clinical Oncology Center, Fukushima Medical University Hospital
  • Munakata Mitsuru
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine

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Other Title
  • 超音波気管支鏡ガイド下針生検(EBUS-TBNA)にて診断した濾胞性リンパ腫の1例

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Abstract

Case. A 57-year-old woman was referred to our hospital because of stridor, dyspnea on effort, and sensations of chest and back oppression. Chest computed tomography (CT) showed right hilar lymphadenopathy (#118). EBUS-TBNA was performed. Tissue specimens obtained by EBUS-TBNA revealed lymphoid follicle-like structure. Frozen specimens obtained by redo EBUS-TBNA later demonstrated IgH gene rearrangement and fusion of IgH-BCL2. Given the results of immunohistochemistry as well as the gene analysis, this case was diagnosed as follicular lymphoma. Conclusion. Accurate diagnosis of lymphoma requires identification of subtypes for subsequent treatment strategies. Thus, it is necessary to make optimal arrangements in advance for obtaining specimens from lesions suspected to be lymphoma by EBUS-TBNA.

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