Relationship between Sedative Effect of Midazolam after Rectal Administration and Age.

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  • ミダゾラム注腸による鎮静度と年齢の相関についての検討

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Transrectally administered midazolam is known to be less effective in younger than in older children. To verify the hypothesis that the difference in effect is based on differences in bioavailability at different ages, we measured plasma concentrations of midazolam in 13 children 8 years old or less. One mg/kg of midazolam was given 30 min before induction of anesthesia. The sedation score was evaluated using a 6-point scale on arrival at the operating room and a blood sample was collected immediately after arterial catheter placement. The data was analyzed by Spearmann's rank coefficent and significance was set at p<0.05. There was a significant correlation between sedative score and patients' age, but not between plasma concentration and patients' age. These results suggest that the difference in sedative effect at different ages is not caused only by differences in bioavailability.

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