Might Anesthetic Drug Interactions for the End-point of MAC Reveal Mechanisms of Drug Action?

DOI 19 References
  • TANIFUJI Yasumasa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Science Department of Anesthesiology, Jikei University School of Medicine
  • MIYANO Kazuko
    Department of Anesthesiology, Jikei University School of Medicine

Bibliographic Information

Other Title
  • MACからみた吸入麻酔薬の作用機序

Search this article

Description

  We now know how intravenous anesthetics act but do not understand where and how inhaled anesthetics act.<br>  Generally two or more drugs are often combined to achieve these end-point-produced interactions labeled as “synergistic”, “additive” or “infra-additive” ; additive interactions suggest a common site of action, and synergistic interactions suggest a different site of action.<br>  Lately Eger et al. have paid attention to synergy, additivity and infra-additivity in drug interactions. They published two papers about this research.<br>  First they searched and selected the available data on anesthetic drug interactions for end-points of hypnosis and immobility (MAC) from the entire PubMed database.<br>  They found that most interactions between drug classes were synergistic, except ketamine, which interacted in either an additive or infra-additive manner. Inhaled anesthetics typically showed synergy with intravenous anesthetics but were additive except in the case of nitrous oxide and isoflurane.<br>  Next they studied the additivity of MAC for 11 inhaled anesthetic pairs defined by differences in potency for a channel/receptor in rats. They also studied 4 additional pairs that included nitrous oxide because of previous reports suggesting a deviation from additivity for the combination of nitrous oxide and isoflurane. The results showed that all combinations produced additivity, except for the combination of isoflurane with nitrous oxide.<br>  Such results are consistent with the notion that inhaled anesthetics act on a single site to produce immobility in the face of noxious stimulation.

Journal

References(19)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top