Autologous Peripheral Blood Mononuclear Cell Implantation for Therapeutic Angiogenesis in a Patient with Buerger's Disease

DOI 11 References
  • KAWAHITO Shinji
    Department of Anesthesiology, Tokushima University Medical and Dental Hospital
  • ISEKI Akio
    Department of Anesthesiology, Tokushima University Medical and Dental Hospital
  • KITAHATA Hiroshi
    Department of Anesthesiology, Tokushima University Medical and Dental Hospital
  • KANBARA Tamotsu
    Department of Cardiovascular Surgery, Tokushima University Medical and Dental Hospital
  • KITAGAWA Tetsuya
    Department of Cardiovascular Surgery, Tokushima University Medical and Dental Hospital
  • OSHITA Shuzo
    Department of Anesthesiology, Tokushima University Medical and Dental Hospital

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  • バージャー病に対する自己末梢血単核球細胞移植による血管新生治療

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Abstract

  We describe herein the successful treatment by therapeutic angiogenesis of a patient with ischemic ulcers and pain of the fingers due to Buerger's disease. A 49-year-old man suffering from Buerger's disease was presented for this novel procedure. Under general anesthesia with sevoflurane, autologous peripheral blood mononuclear cells were manually injected to the ischemic hands. The procedure was completed without any serious complications. The symptoms in his fingers were improved after implantation. However, we had to perform implantation three times due to recurrences. Thus, because autologous peripheral blood mononuclear cell implantation is easier than conventional therapy, and has a lower risk of complications, we recommend this procedure as the therapy of choice in the acute pain phase of Buerger's disease.

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