Monitoring of Brain Metabolism Using Microdialysis during Neuro-Intensive Care
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- KURODA Yasuhiro
- Department of Emergency and Critical Care Medicine, Kagawa University Hospital
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- KAWAKITA Ken-ya
- Department of Emergency and Critical Care Medicine, Kagawa University Hospital
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- YAMASHITA Susumu
- Department of Emergency and Critical Care Medicine, Kagawa University Hospital
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- NAKAMURA Takehiro
- Department of Neurobiology, University of Kagawa, Faculty of Medicine
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- KOTANI Joji
- Department of Emergency and Critical Care Medicine, Hyogo College of Medicine
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- UCHINO Hiroyuki
- Department of Anesthesiology, Hachioji Medical Center, Tokyo Medical University
Bibliographic Information
- Other Title
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- 神経集中治療におけるマイクロダイアリシスによる脳代謝評価
- Monitoring of Brain Metabolism Using Microdialysis during Neuro—Intensive Care
Abstract
Brain microdialysis (MD) is a technique to monitor the concentration of the substances (m. w. under 20 kDa) in the brain's extracellular space using a dialysis probe located in the brain. Brain microdialysis is indicated in severe cases needing monitoring of intracranial pressure or cerebral perfusion pressure. In one patient of traumatic brain injury with brain herniation, extremely low MD glucose and extremely high MD lactate/pyruvate levels were found to suggest anaerobic glycolysis due to the poor supply of oxygen and/or glucose. We also found extremely high MD glutamate and MD glycerol levels which show degradation of the cellular membrane due to brain ischemia. Infusion of osmotic diuretic glycerol produces transient increases in MD glycerol (one case of traumatic brain injury, one case of coma patient after resuscitation from cardiac arrest) . These elevated MD glycerol levels returned to pre-infusion levels after 4-6 hours. Osmotic diuretics glycerol readily enters the brain through the blood brain barrier. We speculate that the infusion interval of osmotic diuretic glycerol was at least 4-6 hours.
Journal
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- THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
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THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 28 (4), 552-562, 2008
THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA
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Details 詳細情報について
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- CRID
- 1390282679735973248
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- NII Article ID
- 130004449776
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- ISSN
- 13499149
- 02854945
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed