PPSB‐HTを投与して管理した第X因子欠乏症の麻酔

DOI 被引用文献1件 参考文献8件 オープンアクセス

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タイトル別名
  • Anesthetic Management for the Patient with Coagulation Factor X Deficiency.

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説明

Coagulation factor X deficiency is a rare homeostatic disorder. Ten cases with factor X deficiency have been reported in Japan and only two of these were operated on. The authors present a case of factor X deficiency successfully treated pen-operatively by freeze-dried human blood-coagulation factor IX (PPSB-HT) administration. The patient was a seventy-one-year-old male with a colon tumor for which transverse colon resection was scheduled. Preoperative examination revealed that the patient had congenital factor X deficiency. To control this homeostatic disorder in the pen-operative period, the authors sought to maintain the blood level of factor X by intravenous administration of PPSB-HT. Prior to the operation, 1, 000 units of PPSB-HT was given intravenously, and the formula estimating the dose necessary to obtain the clinically effective level of factor X was determined. On the day of surgery, the patient received 2, 000 units of PPSB-HT, which was expected to achieve 80∼100% antigen activity. Perioperative hematological study of blood levels of coagulation factor IX, X and PT, APTT values suggested that the patient's hemostatic disorder was adequately controlled by the administration of PPSB-HT at the calculated dose, and intra-operative blood loss was only 75g. The patient experienced no complication and was discharged the hospital.

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