General Aspects of a New Local Anesthetic, Levobupivacaine

DOI 12 References
  • YAMAKAGE Michiaki
    Department of Anesthesiology, Sapporo Medical University School of Medicine

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  • 新しい局所麻酔薬レボブピバカイン概要

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  Bupivacaine has a pipecoloxylidide skeleton and exists as S (-) and R (+) enantiomers (optical isomers) levobupivacaine and dextrobupivacaine, respectively. Marcain® (bupivacaine) is racemic with an enantiomeric ratio of 50: 50 ; however, the novel anesthetic Popscaine® is pharmaceutically formulated from only the S (-) -enantiomer, levobupivacaine. While both enantiomers exhibit concurrent activity, levobupivacaine has greater activity than dextrobupivacaine and causes less cardiovascular compromise. Of the pharmaceutical products approved in April 2008 in Japan, 0.25% product acquired effect-efficacy for postoperative analgesia (epidural administration) and 0.75% one acquired effect-efficacy for epidural anesthetic (peroperative period) .

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