Clinical significance of controlling nutritional status (CONUT) in patients with colorectal cancer

  • Yoshimatsu Kazuhiko
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Sagawa Masano
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Yokomizo Hajime
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Yano Yuki
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Okayama Sachiyo
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Satake Masaya
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Sakuma Akiko
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Matsumoto Atsuo
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Fujimoto Takashi
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Asaka Shinichi
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Usui Takehumi
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Yamaguchi Kentarou
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Shiozawa Shunichi
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Shimakawa Takeshi
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Katsube Takao
    Department of Surgery, Tokyo Women's Medical University Medical Center East
  • Naritaka Yoshihiko
    Department of Surgery, Tokyo Women's Medical University Medical Center East

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Other Title
  • 大腸癌患者におけるcontrolling nutritional status(CONUT)Score の臨床的意義

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Objective : To clarify the clinical significance of the preoperative Controlling Nutritional Status (CONUT) score in patients with colorectal cancer, this study was conducted.<br>Patients and Method : The CONUT cutoff value was obtained based on the relationship to the incidence of surgical site infection (SSI) in 351 patients who underwent colorectal cancer resection using the Receiver operating characteristic curve (ROC curve). Further, the relationship of CONUT and the 5-year survival rate was also analyzed.<br>Results : As the SSI incidence (Grade II or higher) was 9.1% (32 cases), the CONUT cutoff value was 3.0 (AUC ; 0.66, sensitivity 63%, specificity 74%, 95% CI : 0.54-0.76). In patients with CONUT>3.0, the 5-year survival rate was 38.5%, which was significantly lower than the 78.4% rate in patients with CONUT≦3.0 (<0.001).<br>Conclusion : In colorectal cancer patients with preoperative CONUT>3.0, the SSI incidence was high and the prognosis was poor. These results suggest that a study to evaluate malnutritional status of patients using CONUT is necessary to determine whether nutritional intervention can improve the incidence of SSI and prognosis.

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