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Evaluation of the Glasgow Prognostic Score (GPS) in advanced gastric cancer patients undergoing gastro-jejunostomy
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- Nishikawa Kazuhiro
- Osaka General Medical Center, Department of Surgery
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- Iwase Kazuhiro
- Osaka General Medical Center, Department of Surgery
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- Aono Toyokazu
- Osaka General Medical Center, Department of Surgery
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- Takeda Shinichi
- Osaka General Medical Center, Department of Surgery
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- Yoshida Hiroshi
- Osaka General Medical Center, Department of Surgery
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- Nomura Masaya
- Osaka General Medical Center, Department of Surgery
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- Tamagawa Hiroshi
- Osaka General Medical Center, Department of Surgery
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- Omori Kenichi
- Osaka General Medical Center, Department of Surgery
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- Matsuda Chu
- Osaka General Medical Center, Department of Surgery
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- Deguchi Takashi
- Osaka General Medical Center, Department of Surgery
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- Kawada Junji
- Osaka General Medical Center, Department of Surgery
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- Higashi Shigeyoshi
- Osaka General Medical Center, Department of Surgery
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- Deguchi Koichi
- Osaka General Medical Center, Department of Surgery
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- Fushimi Hiroaki
- Osaka General Medical Center, Department of Pathology
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- Fukui Akiko
- Osaka General Medical Center, Department of Nursing
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- Takagi Mari
- Osaka General Medical Center, Department of Pharmacy
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- Fujitani Kazumasa
- Kinki University, Center for Health Affairs
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- Tanaka Yasuhiro
- Osaka General Medical Center, Department of Surgery
Bibliographic Information
- Other Title
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- 進行胃癌バイパス手術症例における Glasgow Prognostic Score(GPS)による予後評価
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Description
The Glasgow Prognostic Score (GPS) is an inflammation-based cumulative prognostic score calculated from C-reactive protein (CRP) and albumin levels. The aim of this study is to assess the value of GPS as a prognostic score in advanced gastric cancer patients undergoing gastro-jejunostomy. We retrospectively reviewed the medical records of 46 advanced gastric cancer patients treated with gastro-jejunostomy. Patients with both an elevated CRP (>1.0 mg/dL) and hypoalbuminemia (<3.5 mg/dL) were assigned a GPS of 2. Patients who presented with one of these biochemical abnormalities were assigned a GPS of 1, and patients with a normal CRP and albumin were assigned a score of 0. Multivariate analyses were performed to evaluate the factors that affected overall survival (OS). These analyses showed that peritoneal metastasis (P1or CY1) (HR : 11.142, 95%CI : 1.290-96.226, p=0.0284), GPS 2 (HR : 11.132, 95%CI : 3.041-40.752, p=0.0003) and treatment without chemotherapy (HR : 14.512, 95%CI : 3.611-58.327, p=0.0002) were independent prognostic factors for shorter OS. ECOG-PS was not a significant independent predictor of survival (HR : 0.617, 95%CI : 0.140-2.723, p=0.5236). Higher GPS grading was associated with shorter OS with median survival times in the groups with a GPS of 0, 1 and 2 were 341, 294 and 174 days respectively. The present study suggests that GPS predicts overall survival in advanced gastric cancer patients undergoing gastro-jejunostomy.
Journal
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- The Japanese Journal of SURGICAL METABOLISM and NUTRITION
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The Japanese Journal of SURGICAL METABOLISM and NUTRITION 47 (6), 171-176, 2013
JAPANESE SOCIETY for SURGICAL METABOLISM and NUTRITION
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Details 詳細情報について
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- CRID
- 1390282679740243840
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- NII Article ID
- 130004893333
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- ISSN
- 21875154
- 03895564
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed