Motor Functions in Patients with Chronic Kidney Disease are Associated with the Difference between eGFRcys and eGFRcreat

DOI
  • SHIOMI Kohei
    Department of Rehabilitation Medicine, University of Tsukuba Hospital Graduate School of Comprehensive Human Science, University of Tsukuba
  • YANAGI Hisako
    Faculty of Medicine, University of Tsukuba
  • SAITO Chie
    Faculty of Medicine, University of Tsukuba
  • NAGAI Kei
    Faculty of Medicine, University of Tsukuba
  • UENO Tomoyuki
    Department of Rehabilitation Medicine, University of Tsukuba Hospital
  • ISHIKAWA Kimihisa
    Department of Rehabilitation Medicine, University of Tsukuba Hospital
  • HADA Yasushi
    Department of Rehabilitation Medicine, University of Tsukuba Hospital
  • YAMAGATA Kunihiro
    Faculty of Medicine, University of Tsukuba

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Other Title
  • 慢性腎臓病患者における運動機能はeGFRcys と eGFRcreat の差と関連する

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<p>Purpose: Estimated glomerular filtration rate (eGFR) based on serum creatinine (eGFRcreat), which is most commonly used for assessing renal function, is influenced by muscle mass. The purpose of this study was to clarify whether the difference between eGFR based on serum cystatin C (eGFRcys) and eGFRcreat is associated with muscle mass or motor functions.</p><p>Methods: The study included 116 patients with pre-dialysis chronic kidney disease (CKD). Skeletal muscle mass was measured by bioelectrical impedance analysis, and motor functions were evaluated based on the grip and isometric knee extension strengths, usual gait speed, and five-times-sit-to-stand test. Patients were divided into two groups based on the difference between eGFRcys and eGFRcreat (eGFRgap). The two groups were compared in terms of motor functions and skeletal muscle mass. Stepwise multivariate regression analysis was used to investigate the factors related to motor functions.</p><p>Results: The group with a higher eGFRgap showed excellent motor functions in all four assessments; however, there was no difference between the two groups in terms of muscle mass. Furthermore, eGFRgap was independently related to motor functions.</p><p>Conclusion: It was suggested that CKD patients with a higher eGFRcys than eGFRcreat had superior motor functions.</p>

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