Predictable soft tissue cutting by an MIR-FEL tuned to 6.05 μm :

DOI 63 References
  • Iwamoto Yumiko
    Graduate School of Science and Engineering, Kinki University
  • Heya Manabu
    Institute of Free Electron Laser, Graduate School of Engineering, Osaka University
  • Hashishin Yuichi
    Graduate School of Science and Engineering, Kinki University
  • Awazu Kunio
    Institute of Free Electron Laser, Graduate School of Engineering, Osaka University
  • Horiike Hiroshi
    Institute of Free Electron Laser, Graduate School of Engineering, Osaka University

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  • 波長６．０５μｍのＭＩＲ‐ＦＥＬ照射による生体軟組織の術前予測的切除：ゼラチン切除
  • ゼラチン切除

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In order to demonstrate basically the usefulness of 6.05-μm-light as the light source for non-invasive soft tissue cutting, we have preliminarily conducted gelatin ablation experiments using a tunable mid-infrared Free Electron Laser (MIR-FEL). It is essential for non-invasive cutting to enable us to precisely predict irradiation effects (such as ablation and denaturation depths) before laser treatment. 6.05-μm-light can resonantly excite both the OH bending of water and the amide-I of proteins. Wet gelatins (including 80-wt% water concentration) were used as the model substance of soft tissue, which consists of 80-wt% water and 20-wt% proteins. The MIR-FEL wavelength was varied within the wavelength range of 5.6-6.7 μm. The incident laser energy density was fixed at 3.6±0.3 J/cm2. The exposure time was 10 s or 100 s. The structural changes of irradiated gelatins were observed with an optical microscope coupled to a CCD camera. The followings can be derived from these observations. (1) Efficient gelatin ablation occurred around 6.05 μm but not 6.45 μm (corresponding to the amide-II of proteins). (2) In the case of 6.05 μm, the wet gelatins were removed due to the pure vaporization of water according to the absorption properties of the wet gelatins before laser treatment, resulting to a predictable laser treatment. In addition, the denaturated area of the gelatins remarkably decreased due to a spectral shift from the OH bending to the amide-I in the absorber as the exposure time is increased (the water in the irradiated gelatins is depleted), leading to the prevention of the formation of thermal coagulum. Thus, 6.05-μm-light can remove predictably soft tissue without unexpected effects and also prevent the formation of undesirable thermal coagulum even if the water concentration remarkably declines. We have proved that 6.05-μm-light is one of the candidates for a predictable soft tissue cutting and/or surgery.

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