Enhanced Effects of PDT by the Use of a Fiber Probe with a Newly Developed Diffuser Tip for Urinary Bladder Tumor

DOI 55 References
  • Miyazaki Kozo
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Morimoto Yuji
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Kumagai Michiaki
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo
  • Fukushima Shigeto
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo
  • Horie Sota
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo
  • Muraoka Miho
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Hu Wei-Zhi
    Applied Optics Products Division, Fujikura Ltd.
  • Nakadate Ken-ichi
    Applied Optics Products Division, Fujikura Ltd.
  • Kaneda Keiji
    Applied Optics Products Division, Fujikura Ltd.
  • Maekawa Yasuhiro
    FiberTech Co., Ltd
  • Shinomiya Nariyoshi
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Nishiyama Nobuhiro
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo
  • Kataoka Kazunori
    Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine,Graduate School of Medicine, The University of Tokyo Departments of Materials Engineering and Bioengineering, Graduate Schools of Engineering, The University of Tokyo

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Other Title
  • 新規開発した膀胱がん対応型均質照射型光ファイバーによるＰＤＴ効果増強

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Photodynamic therapy (PDT) for urinary bladder cancer has not yet been established as a standard clinical treatment. As urinary bladder cancer frequently proliferates multifocally and grows diffusely, homogeneous irradiation of the mucosal membrane on the bladder wall is an important factor for the success of whole bladder wall PDT. In this study, we fabricated a Homogenous Irradiation Fiber Probe (HIFiP) for illuminating the urinary bladder wall and evaluated the PDT effect. Using rat orthotopic urinary bladder tumor models, we confirmed that widespread and homogenous irradiation in the mucosa of the urinary bladder wall was achieved using the newly developed fiber probe. The anti-tumor effect of PDT using HIFiP was approximately 2 times as that using a control fiber (flat cleaved end). An effective PDT for the urinary bladder cancer is expected by the combination of HIFiP and a tumor-selective photosensitizer.

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