Outcome from Photodynamic Therapy with Phospholipid-Conjugated Indocyanine Green for Animal Spontaneous Deep-Seated Occurring Tumors

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  • Okamoto Yoshiharu
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Ohsaki Tomohiro
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Azuma Kazuo
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Itoh Norihiko
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Tsuka Takeshi
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Imagawa Tomohiro
    Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
  • Suganami Akiko
    Department of Bioinformatics, Graduate School of Medicine, Chiba University
  • Tamura Yutaka
    Department of Bioinformatics, Graduate School of Medicine, Chiba University

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  • 深部腫瘍に対するインドシアニングリーン修飾リポソーム（ICG-lipo）と光を用いた治療成績

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We synthesized liposomally formulated phospholipid-conjugated indocyanine green (ICG-lipo). Using the ICG-lipo and a broad band light source or diode laser, we tried to treat against 15 cases of animal spontaneous deep-seated occurring tumors. Irradiation was performed for 20-60 min and its intervals were every day or 3 times per week after injection of the ICG-lipo. Outcome of criteria due to RECIST was followed, CR: one case, PR: eight cases, SD: five cases, PD: one case. QOL was improved in all cases with PR and SD. There was no severe side effect.

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