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Studies on Animal Model of Hereditary Gout
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- Hirai Aizan
- The 2nd Dept. of Internal Medicine, Chiba University, School of Medicine
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- Yamamoto Masahiro
- The 2nd Dept. of Internal Medicine, Chiba University, School of Medicine
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- Kumagai Akira
- The 2nd Dept. of Internal Medicine, Chiba University, School of Medicine
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- Komiyama Tetsuro
- National Institute of Animal Industry
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- Ueno Takashi
- National Institute of Animal Industry
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- Miyazono Yukio
- National Institute of Animal Industry
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- Sajiki Junko
- Chiba Prefectural Institute of Public Health
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- Fujishiro Yoshihiko
- Chiba Prefectural Institute of Public Health
Bibliographic Information
- Other Title
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- 先天性痛風モデル動物に関する研究(第四報)
- Studies on Animal Model of Hereditary Gout Effects of High Protein Diet on Purine Metabolism of hereditary Gouty Chickens
- (副題)先天性痛風鶏の高タンパク食時のプリン代謝動態
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Description
The effects of a high protein diet on purine metabolism in gouty and non-gouty chickens were compared. The daily urinary urate excretion were compared in gouty and non-gouty chickens fed a high protein (40%) and a normo protein (17%) diets. The daily urinary urate excretion in gouty chicken on high protein diet was more than that in non-gouty ones. The activities of six enzymes involved in purine metabolism (G-PRPP-AT, PRPP synthetase, glutamine synthetase, HGPRT, APRT and xanthine dehydrogenase) in the livers of gouty and non-gouty chickens on high and normo protein diets were also compared. The activities of G-PRPP-AT and glutamine synthetase in gouty chicken were more highly induced by a high protein diet than in non-gouty ones. In contrast, HGPRT and APRT activities in gouty chicken were decreased by a high protein diet while those in non-gouty ones were increased. A high protein diet induced PRPP synthetase and xanthine dehydrogenase in similar extent in gouty and nongouty chickens. The hepatic contents of PRPP, glutamine, oxypurine and urate were estimated. A high protein diet increased the hepatic PRPP content both in gouty and non-gouty chickens. On the other hand, the hepatic glutainine content in gouty chicken was decreased by a high protein diet, but not in non-gouty ones. Increase of urate content in the liver was observed only in gouty chicken, and it was twice in nongouty ones. These results suggest that the excessive supply of glutamine is one of the important factors in the accelerated purine and urate biosynthesis in gouty chicken.
Journal
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- Uric acid research
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Uric acid research 2 (2), 160-173, 1978
Japanese Society of Gout and Nucleic Acid Metabolism
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Details 詳細情報について
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- CRID
- 1390282679745482368
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- NII Article ID
- 130003354931
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- ISSN
- 21870098
- 03884120
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
