Distribution and kinetics of lidocaine hydrochloride in the guinea pig

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  • 塩酸リドカインの体内分布および動態

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The distribution of 14C-labelled lidocaine in the guinea pigs after intravenous injection was studied. The mesurements of the radioactivity of several organs were made using a liquid scintillation counter (Packerd Tricarb, Model 460C). General distribution was studied by whole-body autoradiography. The values at 5 and 30 minutes after administration in cerebrum, brain stem, cerebellum were considerable. On the other hand, that of cochlea was a little. A autoradiography, which was made 30 minutes after administration, revealed the distribution of the drug in cerebrum, brain stem, cerebellum, cochlea. 4 hours later, the distribution in cochlea was almost negligible. The distribution in other organs were also negligible 8 hours later. Based on this findings, we speculate that the acting site of lidocaine on tinnitus may be central.

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