ビタミンＡの催奇形性に及ぼすアルカロイドの効果　　奇形耳マウスの実験的研究

DOI

書誌事項

タイトル別名
  • Effect of alkaloid on the teratogenicity of vitamin A. Experimental study concerning ear malformations induced by maternal hypervitaminosis A in the mouse.
  • Experimental Study Concerning Ear Malformations Induced by Maternal Hypervitaminosis A in the Mouse
  • 奇形耳マウスの実験的研究

抄録

Authors showed the inhibitory effect of Cepharanthin, a kind of Alkaloid, on the teratogenicity of maternal hypervitaminosis A in the rat in the previous reports. In the present study, the similar inhibitory effect of Cepharanthin was confirmed in the mouse too. The ddN mother mice were injected intraperitoneally excessive Vitamin A on the 8th day of pregnancy and some of them were injected simultaneously Cepharanthin in the same way. The mouse fetuses from mothers treated with excessive Vitamin A showed external abnormality much more than fetuses from mothers treated with Vitamin A and Cepharanthin. Besides, internal malformations in the ear region observed by means of bone and cartilage staining showed inhibitory effect of Cepharanthin on teratogenicity of excessive Vitamin A as like in the rat.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679746357760
  • NII論文ID
    130004355645
  • DOI
    10.11289/otoljpn1981.18.165
  • ISSN
    18845797
    02889781
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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