顔面神経における単純ヘルペスウイルス感染の実験的研究

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  • The experimental study of herpes simplex virus infection in the facial nerve.

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Herpes simplex virus 1 strain KOS was inoculated to the right auricle of 36 balb/c mice. The data of four mice were excluded because of death. Of the remaining 32 mice, 28 (87.5%) developed ipsilateral facial palarysis between 6 and 9 days after the inoculation. The palarysis lasted for 3 to 7 days in 8 mice which did not recur during follow up of more than 6 months. Four died after occurrence of the facial nerve. Sixteen mice were killed for histological study of the facial nerve. Inflammatory changes, such as round cell infiltration and degeneration of the geniculate ganglion cells, were observed all animals. Herpes simplex virus antigens were indentified in the geniculate ganglion cells, satellite cells and nerve fibers.

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