Evaluation of Anatomical Therapeutic Chemical / Defined Daily Dose and Day of Therapy and the Effect on the Resistance Ratio for <i>Pseudomonas Aeruginosa</i>

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  • Nakamura Yasutaka
    Department of Pharmacy, Osaka City University Hospital Department of Infection Control and Prevention, Osaka City University Hospital
  • Ueno Maki
    Department of Pharmacy, Osaka City University Hospital
  • Nakaie Kiyotaka
    Department of Infection Control and Prevention, Osaka City University Hospital
  • Okada Yasuyo
    Department of Infection Control and Prevention, Osaka City University Hospital
  • Fujita Akiko
    Department of Infection Control and Prevention, Osaka City University Hospital
  • Fujimoto Hiroki
    Department of Infection Control and Prevention, Osaka City University Hospital Infection Control Science, Graduate School of Medicine, Osaka City University
  • Yamada Koichi
    Department of Infection Control and Prevention, Osaka City University Hospital Infection Control Science, Graduate School of Medicine, Osaka City University
  • Nishikawa Takeshi
    Department of Pharmacy, Osaka City University Hospital
  • Nagayama Katsuya
    Department of Pharmacy, Osaka City University Hospital
  • Kakeya Hiroshi
    Department of Infection Control and Prevention, Osaka City University Hospital Infection Control Science, Graduate School of Medicine, Osaka City University

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  • Anatomical Therapeutic Chemical / Defined daily dose（ATC / DDD）とDay of therapy（DOT）の評価と緑膿菌耐性率への影響

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<p>The anatomical therapeutic chemical/defined daily dose system (DDD), recommended by the World Health Organization, uses drug consumption data and calculates the density of antimicrobial agent use and is used at many institutions. The day of therapy (DOT) is an index used to evaluate the density of antimicrobial agent use based on the duration of use and is not related to the daily dose. We determined DDD and DOT semiannually from September 1, 2008, to March 31, 2014, and calculated the ratio of DDD to DOT (DDD / DOT). The DDD / DOT ratio can be used to evaluate the change of the daily dose. We then compared these values and evaluated their effect on the resistance ratio for Pseudomonas aeruginosa. Six drugs were evaluated in this study: ceftazidime, cefozopran, cefepim, imipenem/cilastatin, meropenem, and ciprofloxacin. All drugs, except ciprofloxacin, showed a significant difference between DDD and DOT. The resistance ratio for Pseudomonas aeruginosa was not statistically correlated with three indexes (DDD, DOT, and DDD / DOT). The three indexes (DDD, DOT, and DDD / DOT) can be used to examine the usage trends of antimicrobial agents. However, these three indicators did not show any correlation with the susceptibility rate. Therefore, these indexes should be used on the basis of their characteristics.</p>

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