院内製剤７％リドカインクリームと市販歯科用キシロカイン軟膏の安定性及び局所麻酔効果の比較

DOI NDLデジタルコレクション 参考文献6件

書誌事項

タイトル別名
  • Stability and Clinical Efficancy of 7% Lidocaine Cream and Dental Xylocaine Ointment.

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説明

We compared a 7% lidocaine cream (Preparation C) prepared at our hospital using a commercially available 5% dental xylocaine ointment (Preparation K) for application as a lacal anesthesia for skin patients when employing a laser beam for stability and anesthetic performance. Both preparations did not show any water separation or color change at 5°C, 25°C, 40°C at RH 75% with a 95% or more residual rate. Furthermore, water evaporation in both preparations was not observed and was within the limit of measurement error. Significant change was not recognized in the expansibility of the preparation. The results of the viable cell count study according to Standard Plate-Counting Method and Specific Plate-Counting Method under the four conditions were negative (10 bacteria or less/g) with no observation of bacterial colonies. The anesthetic effect lasted 120 min for Preparation C with the 60-min application, while Preparation K only showed diminution of pain for 30 min.

収録刊行物

  • 病院薬学

    病院薬学 21 (5), 428-433, 1995

    一般社団法人 日本医療薬学会

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